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  Authority of Polish Society of Allergology

vol 18. no 3. September 2013  

 Clinical immunology
Modulation of FcεRI-dependent mast cell activity by inhibitory receptors
Ewa Brzezińska-Błaszczyk

Mast cells are the main effector cells of allergic processes. These cells play a central role in immediate phase of allergic reaction and are involved in chronic allergic inflammation. What is more, mast cell-derived mediators take part in airway remodeling in the course of chronic bronchial asthma. Therefore, it seems to be very important to explain the mechanisms influencing IgE-dependent mast cell activity. This paper describes the down-regulating IgE-mediated mast cell stimulation mechanisms associated with immunoreceptor tyrosine-based inhibition motifs (ITIM), such as FcγRIIB, glycoproteins CD300a and gp49B1, paired immunoglobulin-like receptor B (PIR-B), platelet endothelial cell adhesion molecule-1 (PECAM-1) and CD172a.

keywords: komórki tuczne, mechanizmy alergii, receptory hamujące, mast cells, allergic mechanisms, inhibitory receptors

pages: from 164 to 169

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