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  Authority of Polish Society of Allergology

vol 18. no 2. June 2013  

 Clinical immunology
Interferon alpha in the treatment of respiratory viral infections
Anna Głobińska, Marek L. Kowalski

Interferon alpha belongs to type I family of interferons which are involved in immune response to viral infections. In addition to antiviral properties, IFN-α shows an immunomodulatory and antitumoural activity. Nowadays, IFN-α therapy is applied in chronic hepatitis C infections. Attempts were made to evaluate the clinical applications of interferons in the prophylaxis and treatment of the upper respiratory tract infections; however, their effectiveness was not shown unambiguously. Availability of novel formulations of recombinant interferon creates the possibility to verify clinical efficacy of locally administered interferon in the prophylaxis and treatment of viral infections of the respiratory tract. Thus, the main purpose of this paper is to summarize studies of IFN-α in the therapy of the human airway respiratory diseases.

keywords: interferon-α, wirusy oddechowe, rinowirus, syncytialnywirus oddechowy, przeziębienie, ostre zapalenie oskrzelików, interferon-α, respiratory viruses, rhinovirus, respiratorysyncytial virus, common cold, acute bronchiolitis

pages: from 97 to 103

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