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  Authority of Polish Society of Allergology

vol 18. no 2. June 2013  

 Review articles
Phenotypes of severe asthma in clinical practice
Piotr Łacwik, Maciej Kupczyk, Piotr Kuna

Asthma is a complex disease, characterized by a great heterogeneity of clinical symptoms and mechanisms behind them. A large number of studies performed over the last decade intending to elucidate those relationships resulted in classifying asthma into subgroups known as phenotypes. Several phenotypes were defined based on clinical, cellular and molecular features of asthma. Some of them were linked with specific biomarkers. However, such classification does not help in identifying the pathology behind the disease. Further studies have allowed a better understanding of risk factors and mechanisms of severe asthma. Linking those with phenotypes has resulted in defining asthma endotypes, which combine clinical symptoms with underlying pathology. The results of those studies have already resulted in more efficient usage of currently available asthma treatment, especially the biologic therapies, which are especially effective in precisely defined subtypes of patients. A better understanding of severe asthma pathophysiology can also be of value in development of novel therapies effective against specific mechanisms of the disease.

keywords: astma ciężka, fenotyp, endotyp, patomechanizm, severe asthma, phenotype, endotype, pathomechanism

pages: from 71 to 76

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