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  Authority of Polish Society of Allergology

vol 18. no 1. March 2013  

 Review articles
Differentiation of cutaneous lymphomas and atopic dermatitis– more and more current problem
Małgorzata Sokołowska-Wojdyło, Roman Nowicki

Sézary syndrome (SS) and erythrodermic form of mycosis fungoides (MF)
have been a relatively common subtypes of Cutaneous T-Cell Lymphomas
(CTCL). Atopic dermatitis (AD) is the most common chronic inflammatory
skin diseases and its severe form can manifest as ertytroderma. It is well
known also that severe atopic dermatitis has been a risk factor for development
of the lymphomas. Additionally, the first symptoms of CTCL can
confusingly resemble AD, so dermatologists as well as allergologists are
sometimes faced with a difficult diagnostic problem of determining the
etiology of the dermatosis. The issue is even more complicated because
AD can mimic lymphoma also in histopathological examination (that is
why some authors include AD into the group of pseudolymphomas).
Other features shared by CTCL and AD have been pruritus, elevated IgE
level, elevated level of lactate dehydrogenase, as well as the presence of
Sézary cells in peripheral blood and the positive results of patch tests and
prick tests. The authors take on the task of determining the diagnostic
procedure to be used in daily practice to distinguish between the cases
of patients with AD and suspected CTCL.

keywords: atopowe zapalenie skóry, ziarniniak grzybiasty, zespół Sézary’ego, chłoniaki skórne, różnicowanie,atopic dermatitis, Mycosis fungoides, Sézary syndrome, cutaneous lymphomas, differentiation

pages: from 25 to 31

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