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  Authority of Polish Society of Allergology

vol 18. no 1. March 2013  

 Review articles
Proactive therapy – new therapeutical concept to use topical calcineurin inhibitors in atopic dermatitis
Magdalena Trzeciak, Roman Nowicki

Atopic dermatitis (AD) is highly prevalent, chronic inflammatory skin
disease having characteristic clinical picture with persistent pruritus as
leading symptom. In addition to immunological and genetic factors AD,
skin barrier dysfunction has been implicated in the pathogenesis of AD.
More recently a new treatment approach called “proactive therapy” has
emerged. The new concept is based on chronic application of topical
anti-inflammatory agents, calcineurin inhibitors, which suppress subclinical
inflammation which is present even during clinical the remission of
the disease. Such approach results in more effective treatment of AD.

keywords: atopowe zapalenie skóry, terapia proaktywna, miejscowe inhibitory kalcyneuryny, bariera naskórkowa, atopic dermatitis, proactive therapy, calcineurin inhibitors, skin barrier

pages: from 8 to 13

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