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  Authority of Polish Society of Allergology

vol 17. no 4. December 2012  

 Original articles
Safety and efficacy of grass pollen specific immunotherapy using ultra-rushprotocol and Purethal vaccine
Andrzej Bożek, Jerzy Jarząb

Introduction. Specific immunotherapy (SIT) using ultra-rush protocol in
the treatment of allergy to hymenoptera venom constitutes a safe and
effective therapeutic option.
Aim. SIT with Purethal for grass pollen allergens has been evaluated to
assess its effectiveness and safety.
Materials and methods. The study group consisted of 29 patients with
symptoms of allergic rhinitis and confirmed allergy to grass pollen. Patients
were randomized to ultra-rush therapy or conventional pre- seasonal
SIT. Treatment was carried out during 3 consecutive years.
Results. After three-year treatment, a similar reduction in nasal symptoms
during the pollen season was observed; according to the visual
analog scale (VAS), there was a decrease from 4.228±0.911 scores to
1.922±0.223 in the ultra-rush group and from 4.101±0.733 scores to
2.134±0.223 in the group desensitized by the conventional method
(p>0.05). There was also a comparable reduction in reliever drugs use
during pollen season. No significant differences in safety profile were
observed – only local reactions were noted in both groups.
Conclusions. Ultra-rush SIT with Purethal is effective and safe in the treatment
of grass pollen allergy. However, further investigations on larger
groups of patients are required.

keywords: immunoterapia, alergiczny nieżyt nosa, IgE

pages: from 197 to 201

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