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  Authority of Polish Society of Allergology

vol 17. no 4. December 2012  

 Review articles
Molecular mechanisms of glucocorticoid resistance in bronchial asthma

Glucocorticoids (GCs) are the most potent anti-inflammatory agents,
widely used in the therapy of chronic inflammatory diseases, including
bronchial asthma. The phenomenon of steroid resistance, although relatively
rare, is connected with serious burden for the patient, as well as
with therapeutic problems. So far there are only few available alternative
treatment strategies. Early identification of patients insensitive to GC therapy
is not possible either. Analysis of molecular basis of glucocorticoid
action enables the recognition of those processes that might interfere
with anti-inflammatory steroid effect. This paper describes the known
molecular mechanism of steroid resistance in asthmatic patients, with
particular emphasis on its multifactorial background.

keywords: astma oskrzelowa, receptor glukokortykoidowy, molekularne podłoże steroidooporności

pages: from 180 to 189

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