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Otorhinolaryngology
Allergology Review



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  Authority of Polish Society of Allergology




vol 17. no 4. December 2012  
 TABLE OF CONTENT

 Review articles
Th17 lymphocytes in allergy and asthma
Marek Jutel, Katarzyna Solarewicz-Madejek, Sylwia Smolińska

A new subset of T helper cells (Th), the Th17 cells, constitute a recently
described subpopulation of CD4+ T lymphocytes. They have been distinguished
by their ability to produce a set of characteristic cytokines such
as IL-17, IL-22, IL-17F or chemokines, like CCL20. The main function of
Th17 is immune defence against extracellular pathogens. This function
is executed through activation of different mechanisms of both specific
and nonspecific immune response. In pathological conditions, Th17 cells
play an essential role in the effector mechanisms of chronic inflammation
during autoimmune diseases. However, recent reports point also to
a major role of Th17 cells in chronic inflammation associated with allergic
diseases, such as contact dermatitis, atopic dermatitis and asthma.

keywords: limfocyty Th17, IL-17, mechanizmy alergii, astma, atopowe zapalenie skóry

pages: from 165 to 171



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