|Sylwia Moskwa, Marek L. Kowalski|
The upper and lower airway epithelial cells play a pivotal role in the immune
response to infection with respiratory viruses. They take an active
part in the development and modulation of inflammation by secreting
several cytokines, chemokines and growth factors that attract immune
inflammatory cells. Viral respiratory infections are major aggravating
factors for asthma in both adults and children. Among the respiratory viruses,
it is rhinovirus that is most frequently detected during asthma exacerbations.
Recently it has been demonstrated that the defense response
of the respiratory epithelium to infection with this virus in patients with
asthma is impaired. Understanding the mechanisms of increased susceptibility
of patients with asthma to viral infections may contribute to more
effective prevention and treatment of asthma exacerbations.
keywords: infekcje wirusowe, zaostrzenia astmy, komórki nabłonka
pages: from 127 to 135
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