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  Authority of Polish Society of Allergology

vol 17. no 2. June 2012  

 Review articles
Natural immunological response to respiratory viruses – intracellular signalling pathways
Anna Głobińska, Marek L. Kowalski

Innate immune response to viruses is triggered by recognition of viral
components by pattern recognition receptors (PRRs), which include Tolllike
and RIG-I-like receptors: two major receptor systems for detecting
RNA viruses. In addition to TLRs and RLRs there are also NOD-like receptors,
but their contribution to antiviral response remains controversial.
Sensing of infection is possible due to presence of conserved microbial
structures called pathogen-associated molecular patterns (PAMPs).
Detection of PAMPs induces inflammatory reactions that initiate intracellular
signalling pathways, which leads to activation of transcription
factors and production of proinflammatory cytokines and interferons.
Respiratory viruses, like human rhinovirus, infect airway epithelial cells
and are responsible for symptoms of “common cold” and exacerbations
of bronchial asthma. Other viruses, e.g. parainfluenza virus or respiratory
syncytial virus, can cause severe respiratory disease (bronchiolitis, pneumonia).
Understanding the molecular mechanisms of immune response
to respiratory viruses at the molecular level is essential for development
of new treatment modalities against viral infections. The aim of this paper
is to review non-specific response receptors and intracellular signalling
pathways triggered during the immune response to viral respiratory

keywords: receptory Toll-podobne, receptory RIG-I-podobne,szlaki sygnałowe, komórki nabłonkowe, wirusy oddechowe, Toll-like receptors, RIG-I-receptors, signalling pathways, epithelial cells, respiratory viruses

pages: from 66 to 76

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