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Otorhinolaryngology
Allergology Review



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  Authority of Polish Society of Allergology




vol 17. no 2. June 2012  
 TABLE OF CONTENT

 Review articles
How to detect allergen-specific IgE – in vivo or in vitro?
Joanna Glück

Allergen-specific IgE estimation is the fundamental diagnostic method
in the IgE-mediated allergic hypersensitivity. The in vivo procedures,
i.e., skin tests, are affected by many factors, and this may result in false
findings. A number of laboratory methods of various sensitivity and
specificity levels are used for in vitro IgE determinations. The in vitro
methods are recommended if in vivo tests are impossible to perform
or involve risk to patient’s health. The choice of the diagnostic method
depends also on the type of allergic disease.
In vivo and in vitro tests are concordant at 85-95% for typical IgEmediated
inhalant allergy. Both methods of IgE estimation are used in
drug allergy. However, the standardization of skin tests has been performed
only for few medications and only few commercial laboratory
diagnostics tests against drugs are available. In food allergy, estimation
of IgE is of little relevance and allergen provocation test is the gold
standard of the diagnostics. In Hymenoptera venom allergy, skin prick
and intradermal tests are used as a method of choice because of their
high sensitivity and specificity. The positive result of these tests is sufficient
to make a diagnosis. When skin tests are negative, in vitro serum
IgE tests are necessary.
Thus, IgE tests, that constitute the basis of allergy disease diagnostics,
may be used alternatively with the supplementary tests, depending on
the nosological indications.

keywords: swoiste IgE, in vivo, in vitro, alergia na leki, alergia pokarmowa, allergen-specific IgE, in vivo, in vitro, drug allergy, fodallergy, inhalant allergy, hymenoptera venom allergy

pages: from 51 to 56



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