|Sebastian Żukowski, Marcin Moniuszko, Anna Bodzenta-Łukaszyk|
Introduction. Allergy to birch pollen is one of the most common causes
of allergic rhinitis and conjunctivitis, especially in northern and central
parts of Europe. In a previous study we have shown pre-season clinical
efficacy of specific immunotherapy with birch alergoid.
The aim of study. The aim of the present study was to correlate the immunological
parameters of pre-season immunotherapy with indicators
of allergic inflammation of lower airways.
Material and methods. The study enrolled 21 patients with allergic rhinitis
who were sensitive to birch pollen. Allergen specific immunotherapy
was conducted with the use of birch alergoid. The assessment of efficacy
was performed during the birch pollen seasons with the use of diaries
assessing the severity of symptoms. The evaluation of specific IgE, IgG1
and IgG4 levels was performed before and immediately after the pollen
seasons. The levels of exhaled nitric oxide (NO) were determined before
and during pollen seasons.
Results. The analysis of immune parameters showed a significant increase
in IgG4 antibody levels after the first and second pollen season
in patients receiving the active vaccine. In the same group of patients
we showed no significant differences in the concentrations of specific
IgE and IgG1. The analysis of correlations between NO levels, symptoms
reported in diaries and IgE, IgG1 and IgG4 revealed only the existence of
negative correlation between IgG1 and the level of discomfort during the
peak season in the 2nd season of immunotherapy.
Conclusions. Our results indicate that clinical assessment of pre-season
specific immunotherapy with birch alergoid is not closely correlated with
the degree of change in immune parameters.
keywords: alergiczny nieżyt nosa, immunoterapia swoista, pyłki brzozy, tlenek azotu, NO, immunoglobuliny, IgE, IgG1, IgG4, allergic rhinitis, specific immunotherapy, birch pollen, nitric oxide, immunoglobulin, IgE, IgG1, IgG4
pages: from 194 to 199
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