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  Authority of Polish Society of Allergology

vol 16. no 2. June 2011  

 Review articles
Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) – classification, diagnosis and management: review of the EAACI/ENDA# and GA2LEN/HANNA*
M. L. Kowalski i wsp.

Nonsteroidal anti-inflammatory drugs (NSAIDs) are responsible for
21-25% of reported adverse drug events which include immunological
and nonimmunological hypersensitivity reactions. This study presents
up-to-date information on pathomechanisms, clinical spectrum,
diagnostic tools and management of hyper-sensitivity reactions to
NSAIDs. Clinically, NSAID hypersensitivity is particularly manifested by
bronchial asthma, rhinosinusitis, anaphylaxis or urticaria and variety
of late cutaneous and organ-specific reactions. Diagnosis of hypersensitivity
to a NSAID includes understanding of the underlying mechanism
and is necessary for prevention and management. A stepwise
approach to the diagnosis of hypersensitivity to NSAIDs is proposed,
including clinical history, in vitro testing and/or provocation test with a
culprit or alternative drug depending on the type of the reaction. The
diagnostic process should result in providing the patient with written
information both on forbidden and on alternative drugs.

keywords: nadwrażliwość na aspirynę, alergia na leki, niesteroidowe leki przeciwzapalne, aspirin hypersensitivity, drug allergy

pages: from 57 to 70

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