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  Authority of Polish Society of Allergology

vol 16. no 2. June 2011  

 Review articles
The role of oxidative stress in the pathogenesis of bronchial asthma
Izabela Sadowska-Woda, Edyta Bieszczad-Bedrejczuk

Bronchial asthma is a chronic inflammatory disease of the airways.
Common immune response of both T-helper type 1 and T-helper type
2 cells causes severe airway inflammation. This suggests the importance
of the participation of cytokines produced by both subpopulations
of Th lymphocytes and the activation of transcription factors in respiratory
epithelial cells, as well as the activation of the nuclear factor κB
in the pathophysiology of asthma. Increased activity of the immune
system in asthma leads to increased shifting of the antioxidative-prooxidative
balance in human organism in the direction of oxidation
(oxidative stress) that may initiate or exacerbate inflammation.
On the one hand, the production of reactive oxygen and nitrogen
species is related to the severity of asthma, while on the other hand,
the enzymes (superoxide dismutase, glutathione peroxidase and catalase)
and nonenzymatic factors (glutathione, vitamin A, C and E and
β-carotene) play an important role in the changes in the functioning of
antioxidant defense. The antioxidative-prooxidative imbalance in asthmatics
may lead to increase of the permeability of blood vessels, bronchial
smooth muscle contraction, and increased mucus production by
the glands of the respiratory system. Several therapeutic strategies to
reduce oxidative stress and enhance antioxidant barrier in asthma have
been proposed. Further studies on biomarkers of oxidative stress and
the effectiveness of selected antioxidants in adjuvant therapy of asthma
are needed to determine the optimum control of this disease.

keywords: astma, stres oksydacyjny, antyoksydanty, asthma, oxidative stress, antioxidants

pages: from 80 to 89

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