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  Authority of Polish Society of Allergology

vol 16. no 1. March 2011  

 Review articles
Treatment of gastroesophageal reflux improves asthma control (contra)
Andrzej Obojski

Gastroesophageal reflux disease is defined by the presence of subjective
symptoms which are accompanied (or not) by the damage of esophageal
mucosa. Gastroesophageal reflux disease often coexists with
asthma and deteriorates asthma control. The mechanism of asthma
control deterioration in subjects with gastroesophageal reflux disease
is complex and includes: direct bronchial mucosa irritation with stomach
content (microaspiration), esophageal-bronchial vagal reflex and
esophageal-airway local axon reflex. The impact of GERD treatment
on asthma control remains ambiguous. There are studies suggesting
positive effects, however there are also numerous studies with negative
results, showing no impact of proton-pump inhibitors on airway
hyperresponsiveness, lung function and asthma symptoms.

keywords: refluks żołądkowo-przełykowy, astma, kaszel przewklekły, gastroesophageal reflux, asthma, chronic cough

pages: from 27 to 30

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