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  Authority of Polish Society of Allergology

vol 16. no 1. March 2011  

 Review articles
MeDALL (Mechanisms of the Development of ALLergy): an integrated approach from phenotypes to systems medicine
Marek L. Kowalski i wsp.

The origin of the epidemic of IgE-associated (allergic) diseases is
unclear. MeDALL (Mechanisms of the Development of ALLergy), an
FP7 European Union project (No. 264357), aims to generate novel
knowledge on the mechanisms of initiation of allergy and to propose
early diagnosis, prevention, and targets for therapy. A novel phenotype
definition and an integrative translational approach are needed to
understand how a network of molecular and environmental factors
can lead to complex allergic diseases. A novel, stepwise, large-scale,
and integrative approach will be led by a network of complementary
experts in allergy, epidemiology, allergen biochemistry, immunology,
molecular biology, epigenetics, functional genomics, bioinformatics,
computational and systems biology. The following steps are proposed:
(i) Identification of ‘classical’ and ‘novel’ phenotypes in existing birth
cohorts; (ii) Building discovery of the relevant mechanisms in IgE-associated
allergic diseases in existing longitudinal birth cohorts and
Karelian children; (iii) Validation and redefinition of classical and novel
phenotypes of IgE-associated allergic diseases; and (iv) Translational
integration of systems biology outcomes into health care, including
societal aspects. MeDALL will lead to: (i) A better understanding of allergic
phenotypes, thus expanding current knowledge of the genomic
and environmental determinants of allergic diseases in an integrative
way; (ii) Novel diagnostic tools for the early diagnosis of allergy, targets
for the development of novel treatment modalities, and prevention of
allergic diseases; (iii) Improving the health of European citizens as well
as increasing the competitiveness and boosting the innovative capacity
of Europe, while addressing global health issues and ethical issues.

keywords: MeDALL, mechanizmy, alergia, IgE, medycyna systemowa, proteomika, epigenetyka, transkryptomika, wczesne rozpoznanie, profilaktyka, Program Ramowy 7, mechanisms, allergy, IgE, systems medicine, proteomics, epigenetics, transcriptomics, early diagnosis, pr

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