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Allergology Review

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  Authority of Polish Society of Allergology

vol 16. no 1. March 2011  

 Original articles
Antimicrobial activity of short lipopeptides against clinical strains of Staphylococcus aureus
Małgorzata Dawgul, Wioletta Barańska-Rybak, Katarzyna Greber, Łukasz Guzik, Roman Nowicki, Jerzy Łukasiak, Wojciech Kamysz

Introduction. Staphylococcus aureus colonization constitutes one of
the most common etiological factors of purulent skin diseases. General
overuse of broad spectrum antibiotics induces the development
of resistant strains. Bacterial resistance to β-lactam antibiotics, lincosamides,
macrolides and streptogramines is observed. From patients
diagnosed with Staphylococcal infections, methicillin- (MRSA) and
multiresistant strains are isolated. An urgent need of searching for
new effective substances against SA therefore arises. Short synthetic
lipopeptides seem to be an interesting alternative to conventional
antibiotics as they exhibit high antimicrobial activity against broad
spectrum of bacteria.
Aim of the study. The purpose of this study was to appraise the antimicrobial
activity of lipopeptides against clinical strains of SA.
Material and methods. On 20 clinical SA strains isolated from the
patients of Dermatology Clinic of Medical University of Gdańsk, there
were performed minimal inhibitory concentarion (MIC) test (with
use of serial dilution in Mueller Hinton II broth) and minimal bactericidal
concentration (MBC) test. Both tests were conducted for five
synthetic lipopeptides: Palm-KK-NH2, Palm-KKK-NH2, Palm-KKKK-NH2,
Palm-KG-NH2, Palm-KGK-NH2 and four conventional antibiotics: chloramphenicol,
erythromycin, penicillin G and vancomycin.
Results. Synthetic lipopeptides have displayed high antimistaphylococcal
activity against all tested strains, including strains resistant to
chloramphenicol, erythromycin and penicylin.
Conclusions. The results obtained suggest a huge potential of short
lipopeptides as future antistaphylococcal agents for topical use.

keywords: lipopeptydy, peptydy przeciwdrobnoustrojowe, gronkowiec złocisty, lipopeptides, antimicrobial peptides, Staphylococcus aureus

pages: from 31 to 36

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