|Małgorzata Dawgul, Wioletta Barańska-Rybak, Sylwia Bielińska, Roman Nowicki, Wojciech Kamysz|
Introduction. The pathogenesis of human fungal infections is generally
connected with biofilm formation on the surface of skin, mucosa
or biomaterials, i.e. stents or catheters. In natural conditions microbes
are attached to the surface in human body and produce extracellular
polysaccharides. In effect a well organized three dimensional structure
is created. It is characterized by a higher resistance to conventional
antimicrobials, which causes numerous therapeutic complications.
For this reason the search for new active agents constitutes an urgent
need of the present medicine.
Aim. The goal of this study was to estimate the value of antimicrobial
peptides as potential agents against Candida biofilm.
Material and methods. In this work the reference strain Candida
albicans ATCC 10231 and the following peptides: Citropin 1.1, Palm-
KK-NH2, Palm-RR-NH2, Tachyplesin 3 and Temporin A were used. The
influence of these compounds on the Candida biofilm and on its cohesive
properties were investigated.
Results. All of the tested compounds were active against Candida
biofilm and against Candida cells after their adhesion to the urinary
catheter. Peptides have exhibited the ability to prevent the biofilm
formation. The most active compounds were lipopeptides and Tachyplesin
Conclusions. The results encourage further investigations of the action
of antimicrobial peptides against Candida biofilm.
keywords: biofilm, Candida, peptydy przeciwdrobnoustrojowe, antimicrobial peptides
pages: from 220 to 225
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