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  Authority of Polish Society of Allergology




vol 15. no 2. June 2010  
 TABLE OF CONTENT

 Original articles
The role of food allergens and additives in etiopathogenesis of irritable bowel syndrome
Barbara Rymarczyk, Joanna Glück, Barbara Rogala

Introduction. Irritable Bowel Syndrome18 (IBS) is a very common functional gastrointestinal disorder. The characteristic symptoms and the beneficial influence of dietary elimination strongly suggest that there is a link between food and/or food additives hypersensitivity and the etiopathogenesis of IBS.
Aim. Assessment of food and/or food additives hypersensitivity in patients suffering from IBS, coexistence of other atopic diseases, clinical features and the characteristic of the most frequent trigger factors of food hypersensitivity.
Material and methods. 24 subjects (12 women, 12 men, mean age 46,26±4,21 with the diagnosis of IBS. All of them were asked to answer a few questions concerning detailed medical history, clinical symptoms of food hypersensitivity and nutritional habits. Each of them underwent skin prick tests with 12 most common food allergens (Allergopharma, Nexter, Germany). Allergen-specific IgE serum levels against food allergens were assessed (QuantiScan, Immunogenetics). All of them were asked to assess the effect of the elimination diet.
Results. 54.2% (n=13) subjects reported isolated symptoms from the gastrointestinal tract, 45.8% (n=11, p>0,05) manifested symptoms from other organs. 8.3% (n=2) had a convincing history of anaphylaxis. 7 patients (29.2%) of the analyzed population suffered from another atopic disease: seasonal allergic rhinitis (n=5, 20.8%), seasonal allergic rhinitis and asthma n=1, 4.2%), perennial allergic rhinitis and atopic dermatitis (n=1, 4.2%). 29.2% (n=7) patients reported one foodstuff evoking adverse reactions (only reproducible symptoms were taken into account), 16.7% (n=4) – two foodstuffs, 12.5% (n=3) – 3; 16.7% (n=4) – 4; 8.3% (n=2) – 5. The individual diet had a beneficial effect in 61.5% (n=8) cases. Skin prick tests were helpful in identification of the trigger food factor in 3 cases (12.5%).
Conclusions. Properly modified elimination diet improves the clinical status in the majority of IBS patients. The complex and heterogeneous etiopathology and the impact of psychoneurlogical factors on IBS makes food hypersensitivity very difficult and helps to identify the eliciting factor only in a few cases.

keywords: nadwrażliwość pokarmowa, alergia pokarmowa, zespół jelita drażliwego, food hypersensitivity, food allergy, irritable bowel syndrome

pages: from 92 to 95



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