|Joanna Narbutt, Karolina Przybyłowska, Marcin Zakrzewski, Iwona Stelmach, Piotr Kuna,|
Introduction: Atopic dermatitis (AD) is a chronic, inflammatory skin
disease, often co-existing with other atopic diseases such as asthma,
allergic rhinitis or conjunctivitis. Among multiple etiopathogenic factors,
genetic background including polymorphisms or mutations in
genes encoding proteins involved in a proper epidermal function and
immune response, are widely examined. Th-2 derived cytokines including
IL-13 are believed to play a key role in AD pathogenesis.
Aim of the study: The aim of the study was to assess the -1055 C/T
polymorphism in promoter region of IL-13.
Material and methods: The analysis covered 166 AD patients and
205 healthy controls, living in Central Poland. AD diagnosis was based
on Hanifin and Rajka criteria. The intensity of AD was on average level
(16-39 SCORAD). Polymorphisms in IL-13 promoter region were assessed
by the RFLP-PCR method.
Results: The results analysis revealed a decreased risk for AD development
in the patients who have C/C genotype and carry C allele.
However, genotype C/T and being a carrier of T allele correlated with
the increased risk for the disease occurrence.
Conclusion: Our results as well as literature data suggest a link between
polymorphisms in IL-13 and the risk for AD development in European
populations including people living in Central Poland.
keywords: atopowe zapalenie skóry, polimorfizm -1055 C/T genu IL13, patogeneza, atopic dermatitis, -1055 C/T IL-13 gene polymorphism, pathogenesis
pages: from 259 to 262
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