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Allergology Review

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  Authority of Polish Society of Allergology

vol 14. no 2. June 2009  

 Original articles
Hypogammaglobulinemia in infants and young children: clinical and immunodiagnostic characteristics
Aleksandra Szczawińska-Popłonyk, Anna Zelent, Aleksandra Dachtera, Anna Bręborowicz

Introduction. Hypogammaglobulinemia in infancy and early childhood
is an important clinical, diagnostic and prognostic problem.
Aim of the study. To determine the scale of hypogammaglobulinemia
concerning children diagnosed towards immunodeficiency and
to analyze the prevalence and type of concomitant infections and
diseases, mainly allergies.
Material and methods. A total of 51 children were screened for
primary immune deficiencies.
Results. Hypogammaglobulinemia assessed in 39 children was
transient in 6 (15%) cases. In 11 cases it correlated with quantitative
abnormalities of the lymph cell subsets in peripheral blood. The majority
of children suffered from recurrent respiratory, gastrointestinal
and cutaneous infections and the most frequently observed concomitant
disorders, present in 41% of patients were allergic diseases such
as bronchial asthma, atopic dermatitis and alimentary allergy.
Conclusions. Broadening of the spectrum of immunological diagnostic
methods, including evaluation of the lymph cell function, innate
immunity and engagement of immunogenetics contributed to the
precise establishment of a definitive diagnosis of the immunodeficiency.

keywords: pierwotny niedobór odporności, przemijająca hipogammaglobulinemia niemowląt, alergia, dzieci, primary immunodeficiency, transient hypogammaglobulinemia of infancy, allergy, children

pages: from 121 to 132

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