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  Authority of Polish Society of Allergology

vol 14. no 1. March 2009  

 Review articles
Biological properties of hymenoptera venoms
Krzysztof Pałgan, Zbigniew Bartuzi

Anaphylactic reactions caused by bee stings are a common medical
problem. The structures and characterization of bee venom allergens
have been recently reviewed. Melittin and phospholipase A2, two
major components of bee venom are generally thought to play an
important role in inducing the irritation and allergic reactions associated
with the bee stings. Furthermore, recent reports indicate that
melittin induces membrane permeabilization and lyses procariotic as
well as eucarioctic cells. This mode of action is responsible for its antimicrobial,
anti-tumor and leishmanicidal activities. It has been shown
that melittin is capable of inhibiting replication of some viral gene
expression. Moreover, honeybee venom has also anti-inflammatory
property and can be used in treatment of rheumatoid arthritis.

keywords: jad pszczoły, melittyna, działanie przeciwbakteryjne, reumatoidalne zapalenie stawów, komórki nowotworowe , bee venom, melittin, anti-microbial, rheumatoid arthritis, cencer cells

pages: from 17 to 19

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