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Allergology Review

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  Authority of Polish Society of Allergology

vol 13. no 3. September 2008  

 Original articles
Serum levels of IL-2, IL-10, IL-13, INF-g, and TNF-a in children with asthma and atopic dermatitis (AD)

Introduction. Studies assessing cytokine expression in children with different clinical manifestation of atopy are rare and data are conflicting. Differences in serum cytokine levels could indicate distinctions in the immunopathogenesis of both diseases.
Aim of the study. The study aimed at assessing serum cytokine levels in children with atopic diseases.
Material and methods. 19 children with AD and 37 children with atopic asthma were enrolled in the study. The control group consisted of 18 healthy children. S.aureus was found in the skin lesions in 89.5% examined children with AD. Serum cytokine levels were measured using ELISA (Quantikine human, R&D system Europe, UK).
Results. Serum IL-13 level was significantly higher in AD and asthma than in healthy ones (p=0.002, p=0.0003, respectively). Serum INF-γ level in AD was significantly lower in AD than in healthy and asthma (p=0.0006, p=0.001; respectively), but were similar between asthma and controls. The Severity of AD assessed by SCORAD index and the severity of asthma were correlated with serum IL-10 level. Duration of ICS treatment was inversely correlated with serum IL-13 level.
Conclusions. IL-13 plays the key role in the immunopathogenesis of AD and asthma. INF-γ deficit is vital for pathogenesis of AD and may be relevant to propensity to skin infections.

keywords: cytokiny, AZS, astma, dzieci, cytokines, AD, asthma, children

pages: from 172 to 181

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