wersja polska  
Mediton - Publishing House
Start page  Journals  Books  Conferences  News  Mediton  Contact   
   Journals
print this
   Allergy Asthma Immunology - archive  

Allergy Asthma Immunology
     Archive
     Editorial staff
     Editorial board
     For authors
     Subscription
Otorhinolaryngology
Allergology Review



 Search in articles:
  Authority of Polish Society of Allergology




vol 13. no 1. March 2008  
 TABLE OF CONTENT

 Original articles
Endobronchial provocation test with the Dermatophagoides pteronyssinus antigen and histamine in specific immunotherapy in children with atopic bronchial asthma
Ewa Botulińska, Jolanta Tobolczyk, Jerzy Hofman

Introduction. The diagnosis of atopic bronchial asthma, established on the basis of medical history, skin tests results, and the determination of total and specific IgE concentrations, can be complemented, especially in cases of multifactorial allergy, by an endobronchial provocation test with a specific antigen. This test can also be useful in monitoring specific immunotherapy.
Aim of the study. The aim of the study was to assess the usefulness of endobronchial provocation tests with the acarid antigen of Dermatophagoides pteronnyssinus (specific test) and a histamine (non-specific test) in monitoring allergen immunotherapy in children with atopic bronchial asthma.
Materials and methods. Twenty four patients of both sexes, aged from 9 to 18, were included in the study. Atopic bronchial asthma was diagnosed on the basis of medical history, skin prick tests results and both total and specific IgE concentrations. The diagnosis was confirmed with an endobronchial provocation test with the Dermatophagoides pteronyssinus antigen, performed according to Rayan with the Siergiejko modification. Ten children were qualified for immunotherapy with the acarid antigens with Novo Helisen Depot vaccine and 14 children with the Phostal vaccine. Provocation tests with histamine and acarid antigen were performed before immunotherapy (as the baseline) and after the one-year treatment.
Results. In most patients no significant decrease in bronchial reactivity to specific antigen was demonstrated after 1-year treatment, the differences not achieving statistical significance. In some cases the bronchial reactivity to histamine significantly decreased, as compared with baseline values, but the mean value for the whole study group remained unchanged.
Conclusion. Immunotherapy with a specific allergen, of one year's duration, only resulted in decreased specific and non-specific bronchial reactivity in some patients.

keywords: immunoterapia swoista, dooskrzelowy test prowokacyjny, astma atopowa, specific immunotherapy, endobronchial provocation test, atopic asthma

pages: from 61 to 65



estimated time of download (124 kB)
broadband speed:561282565121024[kbps]
time:269532[sec]


You need to have Adobe Acrobat Reader to view the PDF file. It's free. If you don't have the Adobe Acrobat Reader plugin yet, you can get it HERE.


Start page | Journals | Books | Conferences | News | Mediton | Contact

Copyright © 1996-2020 Mediton Publishing House | All rights reserved.