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Allergology Review

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  Authority of Polish Society of Allergology

vol 13. no 1. March 2008  

 Original articles
Expression of selected chemokines and their receptors in skin lesions and perilesional skin in patients with bullous pemphigoid
Anna Erkiert-Polguj, Agnieszka Żebrowska, Małgorzata Wągrowska-Danilewicz, Marian Danilewicz, Rafał Pawliczak, Elżbieta Waszczykowska

Introduction. Bullous pemphigoid (BP) is autoimmune subepidermal blistering disease. There are inflammatory infiltrates in the dermis, formed by eosinophils and neutrophils. Chemokines are critical for the selective attraction and activation of various leukocyte subsets in the inflammatory process, but little is known about the contribution of chemokines to this diseases.
Aim of the study. The aim of the study was to asses differences in expression of chemokines and their receptors in skin lesions and perilesional skin in BP.
Material and methods. The localization and expression of chemokins in skin lesions and perilesional skin were studied by immunohistochemistry. Moreover the serum concentration of selected cytokines was measured by immunoassays.
Results. Expression of eotaxin, TARC and MCP-1 in the epidermis as well as in inflammatory influxed cells in dermis was detected in skin biopsies from BP patients. Examined chemokines expression was detected in perilesional skin of all patients but it was much lower than in lesional skin. CCR-1, CXCR-1 and CXCR-2 expression was confirmed in lesional as well as perilesional skin. The expression of neither examined chemokines nor their receptors was observed in skin biopsies from healthy people.
Conclusion. In conclusion, these data provides the evidence that chemokines may play an essential role in activating and recruiting leukocytes, which ultimately contribute to the tissue damage in BP. Patients suffering from blister diseases may benefit from the new therapeutic approach relying on blocking chemokines release or their receptors.

keywords: pemfigoid, eotaksyna, TARC, MCP-1, CCR-1, CXCR-1, CXCR-2,pemphigoid, eotaxin, TARC, MCP-1, CCR-1, CXCR-1, CXCR-2

pages: from 32 to 41

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