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  Authority of Polish Society of Allergology

vol 13. no 1. March 2008  

 Bronchial asthma
HMGB-1 as an inflammatory cytokine, potential target of novel anti-inflammatory therapy?
Marek Nocuń, Cezary Pałczyński

HMGB-1 (high mobility group box protein 1) is non-histone chromosomal protein involved in maintenance of proper nucleosome structure and regulation of gene transcription. Recently, HMGB-1 has been identified as a late mediator of inflammation, compared to key proinflammatory cytokines such as interleukin (IL)-1?, or tumor necrosis factor (TNF). HMGB-1 is passively released from the nuclei following cell damage or necrosis (but not apoptosis), as well as is secreted by activated cells. Upon binding to membrane receptors, HMGB-1 activates nuclear factor-kappa B (NF-?B) and affects synthesis of proinflammatory cytokines and growth factors. Moreover, HMGB-1 may have chemoattractant activity and may induce expression of adhesive molecules on cell surface. In consequence, HMGB-1 sends an important signal to immune system, hence the inflammatory process can be triggered near the place of HMGB-1 escape into extracellular milieu. The increase of HMGB-1 synthesis in many diseases accompanied by acute or chronic inflammation proves potent proinflammatory activity of this cytokine-like protein.

keywords: HMGB-1, TNF, zapalenie, prozapalne cytokiny, HMGB, TNF, inflammation, proinflammatory cytokines

pages: from 16 to 22

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