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Allergology Review

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  Authority of Polish Society of Allergology

vol 12. no 1. March 2007  

 Original articles
Allergic sensitization and phenotypes in members of atopic families

Introduction. Atopic allergy often affects the whole family, but organ manifestations and clinical picture may be different in the members of the same family. Studying of atopic families may allow to follow-up the inheritance of the atopic allergy phenotype.
Aim of the study. Analyse the atopic phenotypes in the parents and siblings of children with an atopic diseases.
Material and methods. One hundred families meeting the following criteria were enlisted in the study: a child at the age 6-18 with diagnosed atopic disease who had both parents and siblings. The analysis was based on the results of questionnaire surveys, skin tests and total IgE antibody determinations.
Results. The presence of atopic disease in at least one parent were found in 51% families and among the siblings, the diseases were found in 48% families. In 67% families the skin tests with the airborne allergens were found positive at least in one parent, and at least in one of the siblings in 49% families. Elevated total IgE levels were detected in the majority (65%) of the parents and in nearly half (45%) families in one of the siblings. The allergic sensitization to seasonal allergens was found to be consistent between the child and his/her parents in 64% and to perennial allergens in 73%.
Conclusions. Our results show a high, although varying, degree of conformity in allergy phenotypes between family members.

keywords: rodziny atopowe, astma, nieżyt nosa, całkowity poziom IgE, atopic family, asthma, rhinitis, total IgE

pages: from 35 to 39

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