|MATEUSZ JAGŁA, EWA CICHOCKA-JAROSZ|
Regulatory T cells (Treg) are a phenotypic diverse group of cells responsible for controlling the function of the immune system. These cells are responsible for regulation of immune response and play a leading role in developing immune tolerance through active suppression. To-date, several subtypes of regulatory lymphocytes have been described, the most important of them being CD4+CD25+, NK, Th1 lymphocytes and Tr3 cells. The mechanism, by which regulatory T cells function is dependent on the release of suppressive cytokine (IL-10, TGF-?) or is mediated by cell-to-cell interaction via suppressive surface molecules. Abnormalities in the function of regulatory T cells are important in pathogenesis of numerous autoimmune, allergic and chronic infectious diseases both in animal and human studies. Gaining a full understanding of the physiology of these cells will be helpful in explaining mechanisms important in controlling the immune system activity, and the immunologic or pharmacologic modification of their function may be useful in the future as a new approach to immunotherapy. The objective of this review is to clarify the physiology of regulatory cells, explain their role in various immunologic diseases and show future perspectives for their clinical application.
keywords: limfocyty regulatorowe, limfocyty CD4+CD25+, limfocyty Tr1, limfocyty Th3, tolerancja immunologiczna, Regulatory T cells, lymphocytes CD4+CD25+, lymphocytes Tr1, lymphocytes Th3, immunetolerance
pages: from 22 to 29
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