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  Authority of Polish Society of Allergology

vol 11. no 4. December 2006  

 Original articles
Safety of accelerated immunotherapy build-up schedule with Phostal in asthmatic children allergic to house dust mite

Introduction. Accelerated immunotherapy build-up schedules offer the advantage of reduced number of office visits and cause that the procedure is better tolerated by patients and their carers.
Aim of the study. The aim of this study was to investigate the safety of accelerated immunotherapy build-up schedule with Phostal in children with asthma, allergic to house dust mite
Material and methods. In the randomized control study we compared safety of standard (14 week) and accelerated (9 week) build-up schedule of immunotherapy in 100 asthmatic children allergic to house dust mite.
Results. Ninety nine children were finally enlisted in the study (one child was excluded due to asthma exacerbation). Subcutaneus immunotherapy administered using an accelerated (n=50) and a standard (n=49) protocol was equally safe. There were no differences in local or serious adverse reactions between the study groups.
Conclusion. Accelerated (9-week) schedule used instead of the standard (14-week) build-up schedule of immunotherapy with Phostal did not increase the frequency of adverse effects in asthmatic children allergic to house dust mite.

keywords: przyspieszony schemat odczulania, dzieci, astma oskrzelowa, accelerated immunotherapy, children, bronchial asthma

pages: from 207 to 210

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