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  Authority of Polish Society of Allergology

vol 11. no 4. December 2006  

 Clinical immunology
The role of selected adhesion molecules in the pathogenesis of dermal changes in subepidermal bullous diseases

Pathogenesis of skin lesions in subepidermal bullous diseases like dermatitis herpetiformis (DH) and bullous pemphigoid (BP) is associated with destruction of basement membrane components and anchoring fibers responsible for the skin-epidermis integrity. Autoantibodies binding to autoantigens localized in the basement membrane of the epidermis activate a series of immunological and enzymatic phenomena that lead to blister formation. Skin lesions in DH are histologically characterized by formation of neutrophilic inflammatory infiltrate leading to destruction of basement membrane zone proteins and finally to subepidermal blister. Structural studies revealed that bullous pemphigoid (BP) is characterized by inflammatory infiltrate in the dermis, destruction of hemidesmosomes and matrix proteins. Formation of the inflammatory infiltrations is preceded by early accumulation of lymphocytes, which depends on the activity of the adhesion molecules.
Adhesion molecules are essential for cell-cell and cell-matrix interaction. Integrins and selectins are important for the formation of contact foci, adhesion bands, desmosomes of hemidesmosomes, and for the systemic immunological reaction during the inflammatory process. The aim of the work was to review the literature on the contribution of selected adhesion molecules to the development of dermal changes in subepidermal bullous diseases.

keywords: cząsteczki adhezyjne, integryny, selektyny, podnaskórkowe choroby pęcherzowe, adhesive molecules, integrins, selectins, pemphigoid, subepidermal bullous diseases

pages: from 199 to 206

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