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Allergology Review

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  Authority of Polish Society of Allergology

vol 11. no 3. September 2006  

 Original articles
Pulmonary function in patients with arterial hypertension, bronchial asthma and chronic obstructive pulmonary disease after administration of selective β1-adrenoreceptor antagonists
Monika Ścibor, Grażyna Czerniawska-Mysik, Teresa Adamek-Guzik

Introduction. In the patients with arterial hypertension and concomitant bronchial asthma or chronic obstructive pulmonary disease (COPD), treatment intended to reduce blood pressure should be selected so as to ensure that the pulmonary function is not adversely affected.
Aim of the study. Evaluate the effect of a single dose of metoprolol (50mg) and bisoprolol (5mg) on pulmonary function.
Material and methods. The study was performed in the group of 50 (25 female and 25 male) patients with asthma or COPD and concomitant arterial hypertension. The mean age was 58.38±1.90 years. The influence of the tested drugs on pulmonary function was monitored in terms of the changes of spirometric parameters: FEV1, VC, FVC(EX), FEV1%VC, MEF25, MEF50, MEF75, and peak expiratory flow rate (PEFR), measured by a Wright meter. These tests were performed before administration of the study drugs and after 1 h, 2 hrs, 3 hrs and additionally after 4 hrs in the case of bisoprolol. At the same time points, patient's blood pressure was measured, while PEFR was additionally assessed after 12h.
The control group - 20 hypertensive patients without airway obstruction.
Results. The administration of study drugs caused a statistically significant deterioration in all analysed parameters. The changes of PEFR values after the administration of both drugs were statistically significant (p<0.001) and deteriorated gradually, reaching the poorest values after 2 and 3 hrs for metoprolol and bisoprolol, respectively.
Conclusions. Our results show that selective beta-1-adrenoreceptor antagonist drugs should be used with great care during hypotensive treatment of patients with bronchial asthma or chronic obstructive pulmonary disease.

keywords: metoprolol, bisoprolol, badania spirometryczne, metoprolol, bisoprolol, lung function test

pages: from 143 to 149

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