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Allergology Review

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  Authority of Polish Society of Allergology

vol 11. no 2. June 2006  

 Original articles
IgE-mediated allergy in patients with hereditary angioedema (HAE)

Introduction. Hereditary angioedema (HAE) is rarely diagnosed, and at first it is usually treated as an allergic condition.
Aim of the study. Presentation of clinical symptoms and the results of allergological tests in patients with hereditary angioedema.
Material and methods. We examined 25 patients (7-57 years old) with hereditary angioedema confirmed by complement measurement (C4, C1 inhibitor concentration and C1 inhibitor activity). We analysed clinical symptoms suggestive of allergy and we performed allergological prick tests and specific serum IgE antibody determinations using UniCAP System (Pharmacia, Sweden).
Results. Recurrent angioedema was found in all 25 studied patients, in 19 of them other clinical symptoms were observed: recurrent cough - 10, chronic rhinitis - 15, dermatitis - 2, bronchial dyspnoea - 1. IgE-mediated allergy was detected in 9 (36%): inhalant allergy in 9, and food allergy in one of the patients.
Conclusions. The troubles with early diagnosis of HAE are attributable to the presence of typical symptoms suggestive of an allergy. Recurrent oedemas of subcutaneous tissue without any improvement after a typical treatment may serve as an indication for complement diagnostic tests.

keywords: alergia, dziedziczny obrzęk naczynioruchowy, objawy kliniczne, testy alergologiczne, allergy, clinical symptoms, diagnostic tests, HAE

pages: from 98 to 102

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