Arachidonic acid is one of the most important source of various mediators in bronchial asthma. Arachidonate is derived from phospholipids by phospholipases and then enters the cascade of enzymes delivering a few end-products such as prostaglandins, tromboxanes and leukotrienes and lipoxins.
Leukotrienes are the most powerful and important of arachidonate metabolites. Drugs interfering with its synthesis or actions have been successfully used in treatment of asthma for more than decade. Recently one of them montelukast has also been registered to allergic rhinitis treatment.
Against the common opinion some of the arachidonate metabolites - lipoxins revealed some rather strong anti-inflammatory properties.
This paper delivers a comprehensive review of current data on arachidonate metabolites and their role in bronchial inflammation.
keywords: kwas arachidonowy, eikozanoidy, astma, zapalenie, asthma, inflammation, arachidonic acid, leukotrienes
pages: from 26 to 31