Atopic dermatitis is allergic chronic disease, the prevalence of which has increased over recent decades. According to modified hygienic theory of allergy this increase is the effect of disturbances in commensal intestinal microflora leading to reduced activation of proinflammatory (Th1) immune reactions and regulatory T lymphocytes. Probiotics are defined as live microorganisms which administrated per orally improve host health. Clinical studies showed the beneficial impact of specific probiotics, mainly Lactobacillus and Bifidobacterium strains on clinical symptoms of atopic dermatitis. Probiotics influence the maintenance of Th1/Th2 cytokine homeostasis, the development of oral tolerance against allergens and the improvement of the intestinal barrier.
keywords: atopowe zapalenie skóry, probiotyki, alergia, mikroflora jelitowa, atopic dermatitis, allergy, probiotics, intestinal microflora
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